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Lip cancer develops from abnormal cells that grow out of control and form lesions or tumors on the lips. Lip cancer is a type of oral cancer. It develops in thin, flat cells — called squamous cells — that line the:. Dentists are typically the first to notice signs of lip cancer, often during a routine dental exam. According to the National Institute of Dental and Craniofacial Research , many cases of oral cancer are linked to tobacco use and heavy alcohol use.